JTV 519 fumarate

Catalog #: 4564
2 Citations Datasheet / COA / SDS

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JTV 519 fumarate | CAS No. 1883549-36-7 | Ryanodine Receptor Inhibitors

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Description: Ryanodine receptor (RyR) inhibitor

Alternative Names: K 201

Chemical Name: 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

Technical Data

M.Wt:

540.67

Formula:

C₂₅H₃₂N₂O₂S.C₄H₄O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1883549-36-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

K201 (JTV519) suppresses spontaneous Ca²⁺ release and [³H]ryanodine binding to RyR2 irrespective of FKBP12.6 association.
Hunt et al.
Biochem.J., 2007;404:431
Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes.
Chen et al.
Br.J.Pharmacol., 2008;153:915
Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1.
Ye et al.
Mol.Pharmacol., 2012;81:53

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Citations for JTV 519 fumarate

The citations listed below are publications that use Tocris products. Selected citations for JTV 519 fumarate include:

2 Citations: Showing 1 - 2

Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.
Authors: Andreia S Et al.
Cell Rep Methods 2023;3:100456
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.
Authors: Chih-Cheng Et al.
Elife 2021;10

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