JWH 018
Discontinued Product
Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity: ≥99%
Biological Activity
Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding.
Aung et al.
Drug Alcohol Depend., 2000;60:133 -
The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor.
Chin et al.
J.Pharmacol.Exp.Ther., 1999;291:837 -
3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor.
Huffman et al.
Bioorg.Med.Chem., 2003;11:539
Product Datasheets
Citation for JWH 018
The citations listed below are publications that use Tocris products. Selected citations for JWH 018 include:
1 Citation: Showing 1 - 1
-
Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
Authors: Ford
Pharmacol Res 2017;125:161
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for JWH 018
There are currently no reviews for this product. Be the first to review JWH 018 and earn rewards!
Have you used JWH 018?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
