kb NB 142-70

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1.
   Gan H, Wang G, Hao Q, Wang Q, Tang H
   J Biol Chem, 2014;288(52):37343-54.
2. Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization
   JK Chang, Y Ni, L Han, J Sinnett-Sm, R Jacamo, O Rey, SH Young, E Rozengurt
   J. Biol. Chem., 2017;0(0):.
3. Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells
   F Hao, Q Xu, Y Zhao, JV Stevens, SH Young, J Sinnett-Sm, E Rozengurt
   Mol. Cancer Res., 2017;0(0):.
4. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.
   Ni et al.
   PLoS ONE, 2013;9:e73149
5. Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility.
   LaValle et al.
   BMC Chemical Biology, 2010;10:5
6. Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D.
   Bravo-Altamirano et al.
   ACS Med.Chem.Lett., 2011;2:154

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