Home / Monoacylglycerol Lipase Inhibitors / KML 29

KML 29

Catalog #: 4872
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4872/10
4872/50
KML 29 | CAS No. 1380424-42-9 | Monoacylglycerol Lipase Inhibitors
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Description: Highly potent and selective MAGL inhibitor

Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

KML 29 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).

Technical Data

M.Wt:
549.42
Formula:
C24H21F6NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1380424-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute

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Citations for KML 29

The citations listed below are publications that use Tocris products. Selected citations for KML 29 include:

2 Citations: Showing 1 - 2

  1. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play.
    Authors: Margaret M Et al.
    Neuron  2019;102:435-449.e6
  2. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Authors: Morena Et al.
    Neuropharmacology  2016;111:59

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