KRIBB11
Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
Purity: ≥99%
Biological Activity
KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter.
Yoon YJ, Kim JA, Shin KD et al.
J Biol Chem -
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.
Samarasinghe et al.
Biochem. Pharmacol., 2014;87:445
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