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KU 60019

Catalog #: 4176
14 Citations Datasheet / COA / SDS

Discontinued Product

4176 has been discontinued.
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KU 60019 | CAS No. 925701-46-8 | ATM and ATR Kinase Inhibitors
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Description: Potent ATM kinase inhibitor

Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide

Purity: ≥98%

Product Details
Citations (14)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.

Technical Data

M.Wt:
547.67
Formula:
C30H33N3O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
925701-46-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca.

Product Datasheets

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Citations for KU 60019

The citations listed below are publications that use Tocris products. Selected citations for KU 60019 include:

14 Citations: Showing 1 - 10

  1. Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance.
    Authors: Yang Et al.
    Sci Adv  2018;4:eaat5077
  2. Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.
    Authors: Ryl Et al.
    Cell Syst  2017;5:237
  3. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
    Authors: Jaiswal Et al.
    EMBO J  2017;36:2161
  4. Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.
    Authors: Deng Et al.
    PLoS Pathog  2016;12:e1005399
  5. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
    Authors: Parplys Et al.
    Cell Cycle  2015;43:9817
  6. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression.
    Authors: Koo Et al.
    Nucleic Acids Res  2015;290:7463
  7. Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.
    Authors: Mehta Et al.
    PLoS Pathog  2015;11:e1004763
  8. Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation.
    Authors: Wu Et al.
    J Biol Chem  2014;289:34378
  9. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
    Authors: Barton Et al.
    J Cell Biol  2014;206:877
  10. Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
    Authors: Davari Et al.
    Cell Cycle  2014;13:3659

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