KU14R
Discontinued Product
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole
Purity: ≥99%
Biological Activity
KU14R is a antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent Ins secretagogue in rat and human islets of Langerhans.
Chan et al.
Br.J.Pharmacol., 1997;120:926 -
Clotrimazole and efaroxan stimulate Ins secretion by different mechanisms in rat pancreatic islets.
Chan et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:763 -
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse.
Mayer and Taberner
Eur.J.Pharmacol., 2002;454:95
Product Datasheets
Citation for KU14R
The citations listed below are publications that use Tocris products. Selected citations for KU14R include:
1 Citation: Showing 1 - 1
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Multiple effector pathways regulate the Ins secretory response to the imidazoline RX871024 in isolated rat pancreatic islets.
Authors: Mourtada Et al.
Br J Pharmacol 1999;127:1279
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