Home / NMDA Receptor Antagonists / L-689,560

L-689,560

Catalog #: 0742
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0742/10
0742/50
L-689,560 | CAS No. 139051-78-8 | NMDA Receptor Antagonists
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Description: Highly potent NMDA antagonist

Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline

Purity: ≥99%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

L-689,560 is a very potent antagonist at the glycine-NMDA site.

Technical Data

M.Wt:
380.23
Formula:
C17H15Cl2N3O3
Solubility:
Soluble to 25 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
139051-78-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.

Background References

  1. Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses.
    Clarke V, Molchanova S, Hirvonen T, Taira T, Lauri S
    J Neurosci, 2014;34(50):16902-16.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  4. 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor.
    Leeson et al.
    J.Med.Chem., 1992;35:1954
  5. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
    Stone
    TiPS, 2000;21:149
  6. trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists.
    Leeson et al.
    Med.Chem.Res., 1991;1:64

Product Datasheets

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Citations for L-689,560

The citations listed below are publications that use Tocris products. Selected citations for L-689,560 include:

9 Citations: Showing 1 - 9

  1. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
    Authors: Wall Et al.
    Neuron  2018;98:1124
  2. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  3. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    Mol Brain  2016;26:414
  4. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
    Authors: Fang Et al.
    Toxicol Lett  2015;8:75
  5. Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation.
    Authors: Ng Et al.
    Mol Brain  2014;7:60
  6. The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility.
    Authors: Eales Et al.
    Nat Commun  2014;5:4701
  7. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci  2010;2:1
  8. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
    Authors: Dargan Et al.
    Neuropharmacology  2009;56:121
  9. D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.
    Authors: Rouaud and Billard
    Br J Pharmacol  2003;140:1051

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