L-701,252
Chemical Name: 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
Purity: ≥99%
Biological Activity
L-701,252 is a an antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
Stone
TiPS, 2000;21:149 -
3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex.
Rowley et al.
J.Med.Chem., 1993;36:3386
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