L 760735
Chemical Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
Purity: ≥99%
Biological Activity
L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists.
Duffy et al.
J.Pharmacol.Exp.Ther., 2002;301:536 -
An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.
Harrison et al.
J.Med.Chem., 2001;44:4296 -
Respiratory frequency plasticity during development
SM Johnson, KS Randhawa, TL Baker, JJ Watters
Respir Physiol Neurobiol, 2019;0(0):.
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Citation for L 760735
The citations listed below are publications that use Tocris products. Selected citations for L 760735 include:
1 Citation: Showing 1 - 1
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Crystal structure of the human NK1 tachykinin receptor.
Authors: Yin Et al.
Proc.Natl.Acad.Sci.U.S.A. 2018;115:13264
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