L-803,087 trifluoroacetate
Chemical Name: N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
Purity: ≥97%
Biological Activity
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.
Yamamoto, J, Ohnuma, K, Hatano, R, Okamoto, T, Komiya, E, Yamazaki, H, Iwata, S, Dang, N H, Aoe, K, Kishimoto, T, Yamada, T, Morimoto, C
Br J Cancer, 2014;110(9):2232-45. -
Identification and characterization of subtype selective somatostatin receptor agonists.
Rohrer and Schaeffer
J.Physiol.Paris, 2000;94:211 -
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer et al.
Science, 1998;282:737 -
Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice.
Moneta et al.
Eur.J.Neurosci., 2002;16:843
Product Datasheets
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