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L-NAME hydrochloride

Catalog #: 0665
20 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0665/100
L-NAME hydrochloride | CAS No. 51298-62-5 | Additional NOS Inhibitors
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Description: Non-selective NOS inhibitor

Chemical Name: NG-Nitro-L-arginine methyl ester hydrochloride

Product Details
Citations (20)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

L-NAME hydrochloride is a NO synthase inhibitor.

Technical Data

M.Wt:
269.69
Formula:
C7H15N5O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
51298-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for L-NAME hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:

20 Citations: Showing 1 - 10

  1. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  2. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Proc Natl Acad Sci U S A  2015;35:5664
  3. Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab  2014;34:1128
  4. NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
    Authors: Bice Et al.
    Cardiovasc Res  2014;101:220
  5. Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.
    Authors: Elks Et al.
    PLoS Pathog  2013;9:e1003789
  6. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.
    Authors: Orru Et al.
    Neuropharmacology  2013;67:476
  7. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol  2013;59:20
  8. Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.
    Authors: Townsend and Emala
    Am J Physiol Lung Cell Mol Physiol  2013;305:L396
  9. Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus.
    Authors: Vaish and Singh
    Br J Cancer  2013;2013:312146
  10. Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
    Authors: Gallo and Iadecola
    J Neurosci  2011;31:6947
  11. Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.
    Authors: Dai Et al.
    Am J Physiol Heart Circ Physiol  2011;301:H1248
  12. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
    Authors: Sunters Et al.
    J Biol Chem  2010;285:8743
  13. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  14. Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function.
    Authors: Pearson Et al.
    Am J Physiol Endocrinol Metab  2009;297:E647
  15. Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation.
    Authors: Lou Et al.
    Exp Biol Med (Maywood)  2009;234:1374
  16. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
    Authors: Gibson Et al.
    Neuron  2008;57:746
  17. Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro.
    Authors: Silva Et al.
    Br J Pharmacol  2007;151:195
  18. Endocannabinoids control the induction of cerebellar LTD.
    Authors: Safo and Regehr
    Neuron  2005;48:647
  19. Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
    Authors: Chen Et al.
    J Virol  2002;76:9407
  20. Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    Int J Microbiol  2000;97:11593

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