LDN 193188
Chemical Name: 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
Purity: ≥99%
Biological Activity
LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production.
Shishova et al.
Hepatology, 2011;54:664 -
Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening.
Wagle et al.
Anal.Biochem., 2008;383:85
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