LDV FITC

Catalog #: 4577
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4577/1

1 Image

Description: Fluorescent ligand for α4β1 (VLA-4)

Purity: ≥90%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

LDV FITC is a fluorescent ligand that binds to the α₄β₁ integrin (VLA-4) with high affinity (K_d values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn²⁺ respectively). Used to detect VLA-4 affinity and conformational changes. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

Technical Data

M.Wt:

1368.54

Formula:

C₆₉H₈₁N₁₁O₁₇S

Sequence:

LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-, Lys-6 N-FITC conjugate)

Solubility:

Soluble to 1 mg/ml in PBS (pH 7.4)

Purity:

≥90%

Storage:

Store at -20°C

CAS No:

1207610-07-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

J Neuroinflammation, 2016;13(1):254.
MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands.
Toda S, Segawa K, Nagata S
Blood, 2014;123(25):3963-71.
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn²⁺ or antibody activation.
Chigaev et al.
J.Biol.Chem., 2001;276:48670
Conformational mAb as a tool for integrin ligand discovery.
Njus et al.
Assay Drug Dev.Technol., 2009;7:507
FRET detection of cellular α₄-integrin conformational activation.
Chigaev et al.
Biophys.J., 2003;85:3951

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for LDV FITC

The citations listed below are publications that use Tocris products. Selected citations for LDV FITC include:

1 Citation: Showing 1 - 1

On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction.
Authors: Scott I Et al.
Proc Natl Acad Sci U S A 2013;110:13944-9

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