LE 135

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity
   W Bi, Y Liu, J Guo, Z Lin, J Liu, M Zhou, D Wismeijer, JL Pathak, G Wu
   Cell Biosci, 2018;8(0):48.
2. Adrenergic beta2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro.
   Nijhuis L, Olivier B, Dhawan S, Hilbers F, Boon L, Wolkers M, Samsom J, de Jonge W
   PLoS ONE, 2014;9(1):e85086.
3. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
   Bhatt S, Qin J, Bennett C, Qian S, Fung J, Hamilton T, Lu L
   J Immunol, 2014;192(11):5098-108.
4. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
   Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
   Mucosal Immunol, 2014;7(4):786-801.
5. Retinobenzoic acids. 6. Retinoid antagonists with heterocyclic ring.
   Eyrolles et al.
   J.Med.Chem., 1994;37:1508
6. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
   Umemiya et al.
   J.Med.Chem., 1997;40:4222
7. Identification of a novel class of retinoic acid receptor β-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.
   Li et al.
   J.Biol.Chem., 1999;274:15360
8. All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro
   W Sun, A Shi, D Ma, JGM Bolscher, K Nazmi, ECI Veerman, FJ Bikker, H Lin, G Wu
   FEBS Open Bio, 2020;0(0):.

Product Datasheets