Letrozole
Chemical Name: 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Purity: ≥99%
Biological Activity
Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.
Mitropoulou et al.
Int.J.Cancer, 2003;104:155 -
Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.
Bhatnagar et al.
J.Steroid Biochem.Mol.Biol., 1990;37:1021 -
The discovery and mechanism of action of letr.
Bhatnagar
Breast Cancer Res.Treat., 2007;105:7
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Citations for Letrozole
The citations listed below are publications that use Tocris products. Selected citations for Letrozole include:
4 Citations: Showing 1 - 4
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Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats.
Authors: Xin-Ming Et al.
Int J Mol Sci 2023;24
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Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
Authors: Ali Et al.
BMC Cancer 2017;17:803
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OOE synthesized by female neurons generates sex differences in neuritogenesis.
Authors: Ruiz-Palmero Et al.
Scientific Reports 2016;6:31891
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Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
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