Levcromakalim
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99%
Biological Activity
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.
Buckle et al.
J.Med.Chem., 1991;34:919 -
Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227).
Noack et al.
Br.J.Pharmacol., 1992;107:945 -
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways.
Taylor et al.
J.Pharmacol.Exp.Ther., 1992;261:429
Product Datasheets
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Citations for Levcromakalim
The citations listed below are publications that use Tocris products. Selected citations for Levcromakalim include:
3 Citations: Showing 1 - 3
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TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery.
Authors: Garland Et al.
Br J Pharmacol 2015;172:1114
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Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
Lab Chip 2015;10:e0121634
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Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension.
Authors: Fike Et al.
Pulm Circ 2013;3:551
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