LFM-A13

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets.
   Lopez E, Jardin I, Berna-Erro A, Bermejo N, Salido GM, Sage SO, Rosado JA, Redondo PC
   Cell. Signal., 2012;24(6):1315-22.
2. Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-?B pathway
   F Wang, W Zhang, C Wang, X Fang, H Cheng, S Liu, XL Chen
   Oncotarget, 2017;8(21):34099-34110.
3. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
4. Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets.
   Crosby and Pool
   J.Biol.Chem., 2002;277:9958
5. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide].
   Mahajan et al.
   J.Biol.Chem., 1999;274:9587
6. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.
   Vassilev et al.
   J.Biol.Chem., 1999;274:1646

Product Datasheets