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Linifanib

Catalog #: 7743 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7743/50
7743/10
Linifanib | CAS No. 796967-16-3 | PDGF R beta
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Description: Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Chemical Name: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea

Purity: ≥98%

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Biological Activity

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

Technical Data

M.Wt:
375.4
Formula:
C21H18FN5O
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
796967-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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