LM11A 31 dihydrochloride

Biological Activity

LM11A 31 dihydrochloride is a nonpeptide p75^NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC₅₀ = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC₅₀ = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Small, nonpeptide p75^NTR ligands induce survival signaling and inhibit proNGF-induced death.
   Massa et al.
   J.Neurosci., 2006;26:5288
2. Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.
   Tep et al.
   J.Neurosci., 2013;33:397
3. A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury.
   Shi et al.
   Stem Cells [Epub ahead of print], 2013;
4. A small molecule p75^NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
   Simmons et al.
   PLoS One, 2014;9:e102136

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