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Lomitapide mesylate

Catalog #: 7492 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7492/50
7492/10
Lomitapide mesylate | CAS No. 2059395-52-5 | Lipid Metabolism Inhibitors
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Description: Potent microsomal triglyceride transfer protein (MTP) inhibitor

Chemical Name: N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate

Purity: ≥98%

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Biological Activity

Lomitapide mesylate is a potent inhibitor of microsomal triglyceride transfer protein (IC50 = 8 nM). Lomitapide inhibits or normalizes lipoprotein production in rodents and in a rabbit model of hypercholesterolemia. Lomitapide is antimalarial; it inhibits hemozoin formation and growth of CQ-sensitive (PfNF54) and multidrug-resistant (PfK1) strains of P. falciparum (IC50 values are 0.56 µM and 0.69 µM respectively). Orally bioavailable.

Technical Data

M.Wt:
789.83
Formula:
C39H37F6N3O2.CH3SO3H
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2059395-52-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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