Loreclezole hydrochloride
Chemical Name: (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride
Purity: ≥99%
Biological Activity
Loreclezole hydrochloride is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABAC receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents.
Fisher et al.
Neuropharmacology, 2000;39:235 -
Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents.
Donnelly and Macdonald
Neuropharmacology, 1996;35:1233 -
Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors.
Smith et al.
J.Pharmacol.Exp.Ther., 2004;311:601 -
Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors.
Thomet et al.
Eur.J.Pharmacol., 2000;408:R1
Product Datasheets
Citations for Loreclezole hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Loreclezole hydrochloride include:
2 Citations: Showing 1 - 2
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Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses.
Authors: Lemos Et al.
Neuropsychopharmacology 2011;36:721
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Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
Authors: Kotak Et al.
Mol Med 2008;18:2098
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