LY 233053
Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
Purity: ≥99%
Biological Activity
LY 233053 is a competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-MthD.-aspartic acid antagonist with a short duration of action.
Schoepp et al.
J.Pharmacol.Exp.Ther., 1990;255:1301 -
Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia.
Madden et al.
J.Neurosurg., 1992;76:106 -
Delayed therapy of experimental ischemia with competitive N-MthD.-aspartate antagonists in rabbits.
Madden et al.
Stroke, 1993;24:1068
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