LY 354740
Chemical Name: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Purity: ≥98%
Biological Activity
LY 354740 is a highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and > 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors.
Schoepp et al.
Neuropharmacology, 1997;36:1 -
Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.
Helton et al.
J.Pharmacol.Exp.Ther., 1998;284:651 -
Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.
Klodzinska et al.
Neuropharmacology, 1999;38:1831
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Citations for LY 354740
The citations listed below are publications that use Tocris products. Selected citations for LY 354740 include:
5 Citations: Showing 1 - 5
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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
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Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
Authors: Dornier
Nat Commun 2017;8(1):2255
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
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Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors.
Authors: Copeland Et al.
Sci Rep 2015;92:16
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Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus.
Authors: Yaeger and Trussell
J Neurosci 2015;35:4741
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