M 084 hydrochloride
Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride
Purity: ≥99%
Biological Activity
M 084 hydrochloride is a TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels.
Zhu et al.
Br.J.Pharmacol., 2015;172:3495 -
Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice.
Yang et al.
PLoS One, 2015;10:e0136255
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Citations for M 084 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for M 084 hydrochloride include:
2 Citations: Showing 1 - 2
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Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of Ca2+ into Neurons.
Authors: Melitta Et al.
Int J Mol Sci 2022;23
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DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai and Ford
Cell Rep 2018;25:3148
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