Home / Class II Histone Deacetylases Inhibitors / MC 1568

MC 1568

Catalog #: 4077
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4077/10
4077/50
MC 1568 | CAS No. 852475-26-4 | Class II Histone Deacetylases Inhibitors
1 Image
Description: Selective HDAC class IIa inhibitor

Chemical Name: 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

Purity: ≥96%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MC 1568 is a selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.

Technical Data

M.Wt:
314.31
Formula:
C17H15FN2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥96%
Storage:
Store at +4°C
CAS No:
852475-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines.
    Mai et al.
    J.Med.Chem., 2005;48:3344
  2. Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.
    Mai et al.
    Mol.Pharmacol., 2007;72:1111
  3. Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
    Nebbioso et al.
    EMBO J., 2009;10:776

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for MC 1568

The citations listed below are publications that use Tocris products. Selected citations for MC 1568 include:

1 Citation: Showing 1 - 1

  1. Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo.
    Authors: Verónica Et al.
    Neuropharmacology  2020;165:107922

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for MC 1568

There are currently no reviews for this product. Be the first to review MC 1568 and earn rewards!

Have you used MC 1568?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.