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MCU i4

Catalog #: 7195
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7195/50
MCU i4 | CAS No. 371924-24-2 | Mitochondrial Calcium Uniporter Inhibitors
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Description: Negative modulator of mitochondrial Ca2+ uniporter (MCU)

Chemical Name: 4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.

Technical Data

M.Wt:
377.49
Formula:
C23H27N3O2
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
371924-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A high-throughput screening identifies MICU1 targeting compounds.
    Di Marco et al.
    Cell Rep., 2020;30:2321

Product Datasheets

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Citation for MCU i4

The citations listed below are publications that use Tocris products. Selected citations for MCU i4 include:

1 Citation: Showing 1 - 1

  1. Mitochondria-Endoplasmic Reticulum Interplay Regulates Exo-Cytosis in Human Neuroblastoma Cells.
    Authors: Maria Et al.
    Cells  2022;11

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