MDL 72222
Chemical Name: Tropanyl 3,5-dichlorobenzoate
Purity: ≥99%
Biological Activity
MDL 72222 is a 5-HT3 antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).
Jinka T, Rasley B, Drew K
J Neurochem, 2012;122(5):934-40. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors.
Fozard
Naunyn Schmiedebergs Arch.Pharmacol., 1984;326:36 -
The pharmacology and function of 5-HT3 receptors.
Richardson and Engel
Trends Neurosci., 1986;9:424
Product Datasheets
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Citations for MDL 72222
The citations listed below are publications that use Tocris products. Selected citations for MDL 72222 include:
6 Citations: Showing 1 - 6
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
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Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
Neuropsychopharmacology 2015;40:3015
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Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).
Authors: Jinka Et al.
J Neurochem 2012;122:934
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Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Neuron 2007;54:599
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327
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