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Mesulergine hydrochloride

Catalog #: 1644
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1644/10
1644/50
Mesulergine hydrochloride | CAS No. 72786-12-0 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A and 5-HT2C antagonist; also D2-like partial agonist
Alternative Names: CU-32-085

Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.

Technical Data

M.Wt:
398.95
Formula:
C18H26N4O2S.HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
72786-12-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Mesulergine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:

2 Citations: Showing 1 - 2

  1. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
    Authors: Moutkine Et al.
    J Biol Chem  2017;292:6352
  2. Ergot Alkaloids (Re)generate New Leads as Antiparasitics.
    Authors: Chan Et al.
    Neurotoxicology  2015;9:e0004063

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