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MI 2 (MALT1 inhibitor)

Catalog #: 4848 Datasheet / COA / SDS
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4848/10
4848/50
MI 2 (MALT1 inhibitor) | CAS No. 1047953-91-2 | Additional Synthetic Protease Inhibitors
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Description: MALT1 inhibitor

Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide

Purity: ≥98%

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Biological Activity

MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Technical Data

M.Wt:
455.72
Formula:
C19H17Cl3N4O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1047953-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.
    Fontan et al.
    Cancer Cell, 2012;22:812

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