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Mibefradil dihydrochloride

Catalog #: 2198
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2198/10
2198/50
Mibefradil dihydrochloride | CAS No. 116666-63-8 | Cav3.x Channel Blockers
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Description: CaV3.x blocker
Alternative Names: Ro 40-5967

Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

Purity: ≥97%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Mibefradil dihydrochloride is a Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Technical Data

M.Wt:
568.56
Formula:
C29H38FN3O3.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
116666-63-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Mibefradil dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Mibefradil dihydrochloride include:

9 Citations: Showing 1 - 9

  1. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    Authors: Weber
    PLoS One  2017;12(3):e0172491
  2. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
    Authors: Bragança Et al.
    Front Pharmacol  2016;7:45
  3. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina
    Authors: Prigge Et al.
    The Journal of Neuroscience  2016;6:7184
  4. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
    Authors: Wang Et al.
    Nature  2015;5:16768
  5. DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  6. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels.
    Authors: Stone Et al.
    Sci Rep  2013;543:177
  7. Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells.
    Authors: Weick and Demb
    Neuron  2011;71:166
  8. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability.
    Authors: Grubb and Burrone
    Neurosci Lett  2010;465:1070
  9. Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958

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