Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: Tocris Bioscience
SKU: 3286
Price: 124 USD

Catalog #: 3286
1 Citation Datasheet / COA / SDS

Discontinued Product

3286 has been discontinued.

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Milnacipran hydrochloride | CAS No. 101152-94-7 | 5-HT Transporter Inhibitors

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Description: 5-HT and NA reuptake inhibitor (SNRI)

Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC₅₀ values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α₁-adrenergic and 5-HT_2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

Technical Data

M.Wt:

282.81

Formula:

C₁₅H₂₂N₂O.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

101152-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug.
Moret et al.
Neuropharmacology, 1985;24:1211
Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α₁-adrenergic and serotonergic 5-HT_2A systems.
Maj et al.
J.Neural.Transm., 2000;107:1345
Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation.
Suzuki et al.
Anesth.Analg., 2008;106:1309

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Milnacipran hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:

1 Citation: Showing 1 - 1

The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition.
Authors: Burnham and Dickenson
J Pharmacol Exp Ther 2013;344:696

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