(-)-MK 801 maleate
Chemical Name: (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Purity: ≥99%
Biological Activity
(-)-MK 801 maleate is a less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate.(+)-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.
Genovese and Lu
Psychopharmacology., 1991;105:477 -
Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-MthD.-aspartate antagonists.
Thompson et al.
J.Med.Chem., 1990;33:789
Product Datasheets
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Citations for (-)-MK 801 maleate
The citations listed below are publications that use Tocris products. Selected citations for (-)-MK 801 maleate include:
3 Citations: Showing 1 - 3
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Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites.
Authors: Huang Et al.
J Neurosci 2007;27:9054
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Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
J Pharmacol Exp Ther 2005;25:4288
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Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Authors: Huang Et al.
J Neurosci 2004;24:4551
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