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MitoPY1

Catalog #: 4428
26 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4428/10
MitoPY1 | CAS No. 1041634-69-8 | Fluorescent Cell Indicators and Sensors
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Description: Fluorescent mitochondrial hydrogen peroxide indicator. Used for: live cell imaging. Application: confocal microscopy

Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide

Product Details
Citations (26)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Key information: mitochondria peroxy yellow 1 (MitoPY1) is a fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells.

Used for: imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Can also detect local increases in H2O2 in an in vitro model of Parkinson's Disease.

Application: confocal microscopy.

Properties and Photophysical Data: selective for H2O2 over superoxide, nitric oxide and hydroxyl radical.

Excitation and emission maxima (λ) are 510 nm and 530 nm, respectively, quantum yield = 0.405.

Optical Data for MitoPY1

λabs 510 nm
λem 530 nm
Quantum Yield (φ) 0.405
Application Confocal Imaging

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Technical Data

M.Wt:
954.68
Formula:
C52H53BIN2O5P
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
1041634-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Regents of the University of California

Product Datasheets

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Citations for MitoPY1

The citations listed below are publications that use Tocris products. Selected citations for MitoPY1 include:

26 Citations: Showing 1 - 10

  1. Methods for mitochondrial health assessment by High Content Imaging System.
    Authors: Chayanon Et al.
    MethodsX  2022;9:101685
  2. Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimer's Disease.
    Authors: Maria Et al.
    J Alzheimers Dis  2022;90:565-583
  3. Persistently Elevated Plasma Concentrations of RIPK3, MLKL, HMGB1, and RIPK1 in Patients with COVID-19 in the Intensive Care Unit.
    Authors: Andreas Et al.
    Am J Respir Cell Mol Biol  2022;67:405-408
  4. RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis.
    Authors: Sun Mi Et al.
    Mol Cells  2022;45:193-201
  5. Noncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease.
    Authors: J Et al.
    Function (Oxf)  2022;3:zqac043
  6. Oxidative and Nitrosative Stress Detection in Human Sperm Using Fluorescent Probes.
    Authors: João Et al.
    Methods Mol Biol  2022;2566:45-52
  7. Redox status regulates autophagy in thymic stromal cells and promotes T cell tolerance.
    Authors: Yangming Et al.
    Proc Natl Acad Sci U S A  2022;119:e2204296119
  8. Prognostic significance of chemokines CCL11 and CCL5 modulated by low-density lipoprotein cholesterol in colon cancer patients with normal body mass index.
    Authors: Caihua Et al.
    Ann Transl Med  2021;9:202
  9. Adhesion-mediated mechanosignaling forces mitohormesis.
    Authors: Valerie M Et al.
    Cell Metab  2021;33:1322-1341.e13
  10. Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling.
    Authors: Jorge L Et al.
    BMC Biol  2021;19:57
  11. The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.
    Authors: Maria Et al.
    Neurotherapeutics  2021;18:1017-1038
  12. Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration.
    Authors: Shu-Hao Et al.
    Antioxidants (Basel)  2020;9
  13. Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity.
    Authors: Tong-Shin Et al.
    Redox Biol  2020;37:101751
  14. Measurements of Hydrogen Peroxide and Oxidative DNA Damage in a Cell Model of Premature Aging.
    Authors: Lucio Et al.
    Methods Mol Biol  2020;2144:245-257
  15. Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension.
    Authors: Daria V Et al.
    Front Physiol  2020;10:1588
  16. UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation.
    Authors: Ines Et al.
    J Biol Chem  2019;294:6831-6842
  17. Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells.
    Authors: Moreira Et al.
    Oxid Med Cell Longev  2019;2019:6793957
  18. CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation.
    Authors: Karunakaran Et al.
    Free Radic.Biol.Med.  2019;134:505
  19. Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.
    Authors: Zlatic Et al.
    Cell Syst  2018;6:368
  20. Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.
    Authors: Abuaita Et al.
    Cell Host Microbe  2018;24:625
  21. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
    Authors: Zhang Et al.
    Sci Signal  2018;11
  22. Real-time fluorescence measurements of ROS and [Ca2+} in ischemic/reperfused rat hearts: detectable increases occur only after mitochondrial pore opening and are attenuated by ischaemic preconditioning.
    Authors: Andrienko Et al.
    PLoS One.  2016;11:e0167300
  23. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
    Authors: Camaré Et al.
    Br J Pharmacol  2015;172:106
  24. Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.
    Authors: Griffith Et al.
    Cell Rep  2015;12:1071
  25. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
    Authors: Beyer Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H1587
  26. Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
    Authors: Freed Et al.
    Circ Res  2014;115:525

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