MK 212 hydrochloride

Catalog #: 0941
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0941/10
0941/50

MK 212 hydrochloride | CAS No. 61655-58-1 | 5-HT2C Receptor Agonists

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Description: 5-HT2C agonist

Chemical Name: 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride

Purity: ≥99%

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Product Details

Citations (6)

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Biological Activity

MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT_2C over 5-HT_2A (IC₅₀ values are 0.028 and 0.42 μM for human 5-HT_2C and 5-HT_2A receptors expressed in HEK293 cells respectively).

Technical Data

M.Wt:

235.12

Formula:

C₈H₁₁ClN₄.HCl

Solubility:

Soluble to 50 mM in water with gentle warming

Purity:

≥99%

Storage:

Store at RT

CAS No:

61655-58-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT₂ and 5-HT_1C) receptors.
Conn and Sanders-Bush
J.Pharmacol.Exp.Ther., 1987;242:552
Involvement of 5-HT_2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212.
Hemrick-Luecke and Fuller
Eur.J.Pharmacol., 1996;311:207
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
J.Med.Chem., 2013;56:1211

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MK 212 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for MK 212 hydrochloride include:

6 Citations: Showing 1 - 6

5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-MthD.-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization.
Authors: Bigford Et al.
J Biol Chem 2012;287:11049
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
Authors: Murray Et al.
Nat Med 2010;16:694
Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis.
Authors: Yu and Yamaguchi
J Biomed Sci 2010;103:648
5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
Authors: Yu and Yamaguchi
J Neurophysiol 2009;102:752
Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass.
Authors: Kawahara Et al.
J Neurosci 2008;28:12834

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