ML 130
Chemical Name: 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
Purity: ≥99%
Biological Activity
ML 130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively). Inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Shown to alter subcellular targeting of NOD1; also thought to alter the conformation of NOD1 protein in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.
Correa et al.
Chem.Biol., 2011;18:825 -
Identification of inhibitors of NOD1-induced nuclear factor-κB activation.
Khan et al.
ACS Med.Chem.Lett., 2011;2:780
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ML 130
There are currently no reviews for this product. Be the first to review ML 130 and earn rewards!
Have you used ML 130?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
