ML 348
Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Purity: ≥99%
Biological Activity
ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).
Adibekian et al.
Probe Reports from the NIH Molecular Libraries Program, 2013; -
APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells.
Hernandez et al.
Cell Chem.Bio., 2017;24:87
Product Datasheets
Citations for ML 348
The citations listed below are publications that use Tocris products. Selected citations for ML 348 include:
3 Citations: Showing 1 - 3
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Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Authors: Francisco S Et al.
Nat Chem Biol 2021;17:438-447
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Palmitoylation is required for TNF-R1 signaling.
Authors: Zingler Et al.
Cell Commun Signal 2019;17:90
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Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
Authors: Vujic Et al.
Oncotarget 2016;7:7297
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