ML 354
Discontinued Product
Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
Purity: ≥98%
Biological Activity
ML 354 is a selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354.
Wen et al.
Bioorg.Med.Chem.Lett., 2014;24:4708
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Citation for ML 354
The citations listed below are publications that use Tocris products. Selected citations for ML 354 include:
1 Citation: Showing 1 - 1
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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism.
Authors: Sébert Et al.
Br J Pharmacol 2018;175:3656
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