ML 67-33
Chemical Name: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
Purity: ≥98%
Biological Activity
ML 67-33 is a K2P potassium channel activator (EC50 values are 21.8 - 29.4 μM, 30.2 μM and 27.3 μM for K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) respectively, expressed in xenopus oocytes). Increases channel currents by activating core gating apparatus of channels. In a mouse migraine model, ML 67-33 improves pain symptoms via activation of TREK 1/2 currents in trigeminal ganglion sensory neurons.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Protein and chemical determinants of BL-1249 action and selectivity for K2P channels.
Pope et al.
ACS Chem.Neurosci., 2018;9:3153 -
A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
Bagriantsev et al.
ACS Chem.Biol., 2013;8:1841
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Citation for ML 67-33
The citations listed below are publications that use Tocris products. Selected citations for ML 67-33 include:
1 Citation: Showing 1 - 1
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TREK channel activation suppresses migraine pain phenotype.
Authors: Prado Et al.
iScience 2021;24:102961
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