MM 11253
Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
Purity: ≥98%
Biological Activity
MM 11253 is a selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Suppression by an RAR-? Agonist of Collagen Degradation Mediated by Corneal Fibroblasts
K Kimura, H Zhou, T Orita, M Kobayashi, T Nishida, KH Sonoda
Invest. Ophthalmol. Vis. Sci., 2017;58(4):2250-2257. -
All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity
W Bi, Y Liu, J Guo, Z Lin, J Liu, M Zhou, D Wismeijer, JL Pathak, G Wu
Cell Biosci, 2018;8(0):48. -
Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.
Li Y, Wong K, Walsh K, Gao B, Zang M
J Biol Chem, 2013;288(15):10490-504. -
Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors.
Holmes et al.
J.Cell.Physiol., 2000;185:61 -
Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids.
Le et al.
Oncogene, 2000;19:1457 -
Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.
Dawson et al.
Cancer Res., 2001;61:4723
Product Datasheets
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Citations for MM 11253
The citations listed below are publications that use Tocris products. Selected citations for MM 11253 include:
7 Citations: Showing 1 - 7
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Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase.
Authors: Takashi Et al.
Cancer Cell Int 2023;23:94
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Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway.
Authors: Ning Et al.
Cell Death Dis 2023;14:51
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All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity.
Authors: Bi Et al.
Cell Biosci 2018;8:48
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RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Authors: Metzler Et al.
Development 2018;145
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Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.
Authors: Uchibe Et al.
J Orthop Res 2017;35:1096
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BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
Authors: Perri Et al.
Exp Cell Res 2014;327:183
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Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.
Authors: Garnaas Et al.
Dev Biol 2012;372:178
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