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Mouse C1qR1/CD93 Antibody

Catalog #: MAB1696
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1696
MAB1696-SP
Detection of C1q R1/CD93 in M1 Mouse Cell Line by Flow Cytometry.
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Citations (4)
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Mouse C1qR1/CD93 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse C1q R1/CD93 in direct ELISAs.
Source
Monoclonal Rat IgG2B Clone # 223437
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse C1q R1/CD93
Ala23-Asn572
Accession # O89103
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
8-25 µg/mL
Immersion fixed M1 mouse myeloid leukemia cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of C1q R1/CD93 antibody in M1 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of C1q R1/CD93 in M1 Mouse Cell Line by Flow Cytometry. M1 mouse myeloid leukemia cell line was stained with Mouse C1q R1/CD93 Monoclonal Antibody (Catalog # MAB1696, filled histogram) or isotype control antibody (Catalog # MAB0061, open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG F(ab')2Secondary Antibody (Catalog # F0113).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: C1qR1/CD93

Complement component 1, q subcomponent receptor (C1q R1), also known as C1q Rp, Collectin receptor and AA4 antigen in rodents, mediates enhanced phagocytosis by monocytes and macrophages upon interaction with soluble defense collagens including C1q, MBL (mannose-binding lectin) and SP-A (pulmonary surfactant protein A) (1, 2). It is a type I transmembrane glycoprotein expressed on endothelial cells, hematopoietic progenitor cells, platelets and cells of myeloid origin. C1q R1 has also been identified as a stem cell marker (3, 4).

References
  1. Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
  2. Dean, Y.D. et al. (2001) Eur. J. Immunol. 31:1370.
  3. Petrenko, O. et al. (1999) Immunity 10:691.
  4. Danet, G.H. et al. (2002) Proc. Natl. Acad. Sci. USA 99:1044.
Long Name
Complement Component C1q Receptor
Entrez Gene IDs
22918 (Human); 17064 (Mouse); 84398 (Rat)
Alternate Names
AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4

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Citations for Mouse C1qR1/CD93 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer
    Authors: Kabir A. Khan, José L. Ponce de Léon, Madeleine Benguigui, Ping Xu, Annabelle Chow, William Cruz-Muñoz et al.
    npj Breast Cancer
  2. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state
    Authors: Ghazal Zekavat, Raha Mozaffari, Vanessa J. Arias, Susan Y. Rostami, Armen Badkerhanian, Andrea J. Tenner et al.
    Immunogenetics
  3. Alignment of single-cell trajectories to compare cellular expression dynamics
    Authors: A Alpert, LS Moore, T Dubovik, SS Shen-Orr
    Nat. Methods, 2018-03-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: CyTof
  4. Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis.
    Authors: Greenlee-Wacker MC, Briseno C, Galvan M, Moriel G, Velazquez P, Bohlson SS
    J. Immunol., 2011-08-17;187(6):3353-61.
    Species: Mouse
    Sample Types: Peritoneal Lavage Fluid, Whole Tissue
    Applications: ELISA Development, IHC-P

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