Mouse Cardiotrophin-1/CT-1 Antibody Summary
Ser2-Ala203
Accession # Q60753
Applications
Mouse Cardiotrophin-1/CT-1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Cardiotrophin-1/CT-1
Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Mouse CT-1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross-species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has also been implicated in the receptor complex.
Product Datasheets
Citations for Mouse Cardiotrophin-1/CT-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
4
Citations: Showing 1 - 4
Filter your results:
Filter by:
-
Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease
Authors: Perretta-Tejedor, N;Price, KL;Jafree, DJ;Pomeranz, G;Kolatsi-Joannou, M;Martínez-Salgado, C;Long, DA;Vasilopoulou, E;
Physiological reports
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice
Authors: AI Sánchez-Ga, V Prieto-Vic, V Blanco-Goz, M Arévalo, Y Quiros, D López-Mont, FJ López-Hern, A Rodríguez-, JM López-Novo
J Clin Med, 2019-12-01;8(12):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
Authors: Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA
J. Bone Miner. Res., 2008-12-01;23(12):2025-32.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
J. Cell. Physiol., 2005-08-01;204(2):428-36.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Mouse Cardiotrophin-1/CT-1 Antibody
There are currently no reviews for this product. Be the first to review Mouse Cardiotrophin-1/CT-1 Antibody and earn rewards!
Have you used Mouse Cardiotrophin-1/CT-1 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
