Mouse CCR6 (NP_001177267) VersaClone cDNA

Mouse CCR6 (NP_001177267) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CCR6

CCR6 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Human CCR6 is 374 amino acids (aa) in length with a predicted molecular weight of 42 kDa. Mouse and rat CCR6 share 75% and 76% aa sequence identity with the human protein, respectively. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.

Related Research Areas

• B Cell Chemotaxis, Migration, and Adhesion
• CC Chemokines and Receptors
• Chemokine Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• Dendritic Cell Adhesion and Migration
• G Protein-Coupled Receptors in Immune Responses
• gamma delta T Cells
• LTi Cells
• Monocyte Markers
• Natural Killer T (NKT) Cells
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion
• Th17 Cells
• Th22 Cells