Mouse CD39L3/ENTPD3 Biotinylated Antibody

Catalog #: BAF4464 Datasheet / COA / SDS

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BAF4464

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Mouse CD39L3/ENTPD3 Biotinylated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CD39L3/ENTPD3 in Western blots. In Western blots, approximately 35% cross-reactivity with recombinant human CD39L3 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant mouse CD39L3/ENTPD3
Gln44-Pro485
Accession # AAH79871

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Mouse CD39L3/ENTPD3 (Catalog # 4464-EN)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD39L3/ENTPD3

Ectonucleoside triphosphate diphosphohydrolase-3 (NTPDase-3) is an integral membrane protein with an extracellular catalytic domain (1). rhNTPDase-3 was expressed as a protein lacking its N- and C-terminal transmembrane domains, resulting in the secretion of the soluble rhNTPDase-3 ectodomain. NTPDase-3 hydrolyzes the beta - and gamma -phosphate groups of nucleotides, preferring ATP, ADP, UTP, and UDP as substrates (1). Through its hydrolysis of extracellular nuceotides, NTPDase-3 is important for the regulation of purinergic signaling (2). The enzyme is expressed at its highest levels in brain, pancreas, spleen, and prostate tissues (3). In the brain, NTPDase-3 may play a role in the regulation of feeding, sleep, and other behaviors (4).

References

Lavoie, E.G. et al. (2004) Biochem. Pharmacol. 67:1917.
Crawford, P.A. et al. (2007) Arch. Biochem. Biophys. 457:7.
Chadwick, B.P. and A.M. Frischauf (1998) Genomics 50:357.
Belcher, S.M. et al. (2006) Neuroscience 137:1331.

Long Name

Ecto-Nucleoside Triphosphate Diphosphohydrolase 3

Entrez Gene IDs

956 (Human); 215446 (Mouse); 316077 (Rat)

Alternate Names

ATPDase; CD39 antigen-like 3; CD39L3; CD39L3EC 3.6.1.5; CD39-like 3; EC 3.6.1; Ecto-apyrase 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPase 3; Ecto-ATPDase 3; ectonucleoside triphosphate diphosphohydrolase 3; ENTPD3; FLJ93839; HB6; HB6NTPDase 3; NTPDase-3