Mouse CD40/TNFRSF5 Antibody Summary
Val24-Arg193
Accession # P27512
Applications
Mouse CD40/TNFRSF5 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD40/TNFRSF5
CD40 is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. The mature mCD40 consists of a 172 amino acid (aa) extracellular domain, a 22 aa transmembrane region and a 90 aa cytoplasmic domain (1). CD40 is expressed on B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells and several tumor cell lines (2). The extracellular domain has the cysteine-rich repeat regions, which are characteristic for many of the receptors of the TNF superfamily. Interaction of CD40 with its ligand, CD40L, leads to the aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Interaction between CD40L on T cells and CD40 on B cells stimulated B cell proliferation and provided the signal for immunoglobulin isotype switching (3). Mutations in the CD40L gene, which resulted in a CD40L molecule unable to interact with CD40, are responsible for the hyper-IgM syndrome (4). Cross-linking of CD40 with antibodies or by binding to CD40L produces cell type-specific responses which include costimulation and induction of proliferation, induction of cytokine production, rescue from apoptosis, and upregulation of adhesion molecules (5). Some of the early events of intracellular signaling by the CD40-CD40L system include the association of the CD40 with TRAFs and the activation of various kinases (6‑8).
- Torres, R.M. and E.A. Clark (1992) J. Immunol. 148:620.
- Schonbeck, U. et al. (1997) J. Biol. Chem. 272:19569.
- Armitage, R.J. et al. (1993) J. Immunol. 150:3671.
- Callard, R.E. et al. (1993) Immunol. Today 14:559.
- Stout, R.D. and J. Suttles (1996) Immunol. Today 17:487.
- Pullen, S.S. et al. (1999) Biochemistry 38:10168.
- Faris, M. et al. (1994) J. Exp. Med. 179:1923.
- Hanissian, S.H. and R.S. Geha (1997) Immunity 6:379.
Product Datasheets
Citations for Mouse CD40/TNFRSF5 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Sex-specific transcriptional and proteomic signatures in schizophrenia
Authors: J Tiihonen, M Koskuvi, M Storvik, I Hyötyläine, Y Gao, KA Puttonen, R Giniatulli, E Poguzhelsk, I Ojansuu, O Vaurio, TD Cannon, J Lönnqvist, S Therman, J Suvisaari, J Kaprio, L Cheng, AF Hill, M Lähteenvuo, J Tohka, R Giniatulli, Š Lehtonen, J Koistinaho
Nat Commun, 2019-09-02;10(1):3933.
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Angiogenic activity mediates bone repair from human pluripotent stem cell-derived osteogenic cells
Authors: Li Zou, Qingshan Chen, Zachary Quanbeck, Joan E. Bechtold, Dan S. Kaufman
Scientific Reports
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Incorporation of CD40 ligand enhances the immunogenicity of tumor‑associated calcium signal transducer 2 virus‑like particles against lung cancer
Authors: Wang Xi, Dong Ke, Long Min, Wang Lin, Zuo Jiahui, Lin Fang et al.
International Journal of Molecular Medicine
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Response patterns of cytokines/chemokines in two murine strains after irradiation.
Authors: Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
Cytokine, 2012-01-25;58(2):169-77.
Species: Mouse
Sample Types: Plasma
Applications: Luminex Development -
Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
Authors: I Fagerlund, A Dougalis, A Shakirzyan, M Gómez-Budi, A Pelkonen, H Konttinen, S Ohtonen, MF Fazaludeen, M Koskuvi, J Kuusisto, D Hernández, A Pebay, J Koistinaho, T Rauramaa, Š Lehtonen, P Korhonen, T Malm
Cells, 2021-12-30;11(1):.
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Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation
Authors: Nienke Roescher, Jelle L. Vosters, Zhenan Lai, Toshimitsu Uede, Paul P. Tak, John A. Chiorini
PLoS ONE
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Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1-Dependent Manner
Authors: M Hou, W Wang, F Hu, Y Zhang, D Yang, Q Liu
Infect. Immun., 2018-12-19;87(1):.
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Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells
Authors: P Walsh, V Truong, C Hill, ND Stoflet, J Baden, WC Low, SA Keirstead, JR Dutton, AM Parr
Cell Transplant, 2017-12-01;26(12):1890-1902.
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CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons
Authors: Paulina Carriba, Alun M Davies
eLife
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The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency
Authors: CY Yu, TC Li, YY Wu, CH Yeh, W Chiang, CY Chuang, HC Kuo
Nat Commun, 2017-10-27;8(1):1149.
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