Home / Complement Component C1rLP / Mouse Complement Component C1rLP Antibody

Mouse Complement Component C1rLP Antibody

Catalog #: AF3990
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF3990
AF3990-SP
Product Details
Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Complement Component C1rLP Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Complement Component C1rLP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross‑reactivity with recombinant human (rh) C1rLP is observed and less than 1% cross‑reactivity with rhC1R and rhC1S is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Complement Component C1rLP
Ser18-Asp456
Accession # AAP41417
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse Complement Component C1rLP
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Mouse Complement Component C1rLP, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Component C1rLP

Mouse C1rLP, also CLSPa, is a 55 kDa, secreted, atypical glycoprotein member of the AGY group of servine proteases. It has protease activity for pro-haptoglobin, but accomplishes cleavage without a typical Asp in the catalytic site. In addition, it is proposed to block unwanted complement-mediated proteolysis. Mature C1rLP is 443 amino acids (aa) in length. It contains one CUB domain (aa 43‑165), a truncated CCP2 region (aa 167‑223) and a serine protease domain (aa 239‑482). There is a potential short form that utilizes an alternate start site at Met 27. Over aa 44‑456, mouse C1rLP is 78% and 90% aa identical to human and rat C1rLP, respectively.

Long Name
Complement C1r Subcomponent-like Protein
Entrez Gene IDs
51279 (Human); 232371 (Mouse)
Alternate Names
C1RL; C1RL1; C1RL1complement C1r subcomponent-like protein; C1r-like protein; C1r-like serine protease analog protein; C1r-LPcomplement C1r-like proteinase; C1RLPEC 3.4.21.-; CLSPa; complement component 1, r subcomponent-like; Complement Component C1rLP; EC 3.4.21; EC 3.4.21.41

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Citation for Mouse Complement Component C1rLP Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
    Authors: Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL
    Blood, 2008-03-27;111(11):5316-25.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot

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