Mouse gp130 APC-conjugated Antibody Summary
Gln23-Glu617 (predicted)
Accession # Q6PDI9
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of gp130 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CD3 PE-conjugated Monoclonal Antibody (Catalog # FAB4841P) and either (A) Rat Anti-Mouse gp130 APC-conjugated Monoclonal Antibody (Catalog # FAB4681A) or (B) Rat IgG2AAllophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: gp130
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the class I cytokine receptor family. Binding of IL-6 (IL-11) to either the membrane-anchored or soluble IL-6 R (IL-11 R) initiates the association of IL-6 R (IL-11 R) with gp130 which then undergoes homo-dimerization and signal transduction. With other IL-6 family cytokines, such as LIF and OSM, signal transduction is triggered by the hetero-dimerization of gp130 and LIF R or OSM R.
Gp130 is expressed in all organs examined. Soluble gp130, which apparently arises either from proteolytic cleavage of the membrane-bound receptor or from alternative splicing, has been detected in human serum. The in vivo functions of soluble gp130 are not clearly understood. In in vitro experiments, natural or recombinant soluble gp130 has been shown to have inhibitory effects on OSM and CNTF activities.
- Narazaki, M. et al. (1993) Blood 82:1120.
- Taga, T. and T. Kishimoto (1997) Annu. Rev. Immunol. 15:797.
Product Datasheets
Citations for Mouse gp130 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation
Authors: Gupta, D;Orehek, S;Turunen, J;O'Donovan, L;Gait, MJ;El-Andaloussi, S;Wood, MJA;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development
Authors: H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So
J Immunol, 2016-04-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.
Authors: Pratama, Alvin, Srivastava, Monika, Williams, Naomi J, Papa, Ilenia, Lee, Sau K, Dinh, Xuyen T, Hutloff, Andreas, Jordan, Margaret, Zhao, Jimmy L, Casellas, Rafael, Athanasopoulos, Vicki, Vinuesa, Carola G
Nat Commun, 2015-03-06;6(0):6436.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Authors: Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
Nat Immunol, 2014-03-30;15(5):449-56.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.
J. Immunol., 2011-05-23;187(1):350-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
Authors: Liao W, Lin JX, Wang L, Li P, Leonard WJ
Nat. Immunol., 2011-04-24;12(6):551-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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