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Mouse GPR4 (NP_783599) VersaClone cDNA

Catalog #: RDC0777 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
RDC0777
R&D Systems VersaClone cDNA Plasmids
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Mouse GPR4 (NP_783599) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Mouse

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Background: GPR4

The activation of GPR4, a proton-sensing G protein-coupled receptor, by isocapnic acidosis increases the adhesiveness of human umbilical vein endothelial cells (HUVECs) that express GPR4 endogenously. Acidosis in combination with GPR4 overexpression further augments HUVEC adhesion with U937 monocytes. Activation of GPR4 increases the expression of vascular adhesion molecules E-selectin, VCAM-1 and ICAM-1, which are functionally involved in acidosis/GPR4-mediated HUVEC adhesion. Acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway and may play a role in the inflammatory response of vascular endothelial cells.

Long Name
G Protein-coupled Receptor 4
Entrez Gene IDs
2828 (Human); 319197 (Mouse); 308408 (Rat)
Alternate Names
G protein-coupled receptor 4; GPR19; GPR4; G-protein coupled receptor 19; G-protein coupled receptor 4

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