Mouse ICAM-5 Biotinylated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: ICAM-5

Intercellular adhesion molecule-5 (ICAM‑5), also known as telencephalin, is an integral membrane glycoprotein expressed in neurons of mammalian telencephalons. ICAM‑5 is a member of the immunoglobulin superfamily and shares 38‑55% amino acid homology with other ICAMs. Structurally, ICAM‑5 contains nine Ig domains that included 15 N-glycosylation sites, a single transmembrane region, and C‑terminal cytoplasmic tail (1). As with other members of the ICAM family, ICAM‑5 has been shown to be involved in cellular adhesion. ICAM‑5 binds to the leukocyte integrin LFA-1 (CD11a/CD18) via its first NH2-terminal Ig domain. The ability of ICAM‑5 to bind LFA-1 suggests that ICAM‑5 may play an important role in immune responses in the central nervous system (2). Additionally, ICAM‑5 has been found to promote homophilic binding via binding of the first Ig domain to Ig domains 4‑5. Homophilic adhesion activity of ICAM‑5 is regulated by a monomer/tetramer transition. ICAM‑5 expression temporally parallels the onset of dendritic elongation and synaptogenesis during the postnatal period suggesting that ICAM‑5 may provide a brain segment-specific cue for synaptogenesis or dendrite-dendrite interaction (3).

Product Datasheets

Related Research Areas

• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Immunoglobulin Superfamily CAMs
• Microglia Homeostasis