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Mouse IFN-alpha Antibody

Catalog #: 22100-1
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
22100-1
Product Details
Citations (6)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse IFN-alpha Antibody Summary

Species Reactivity
Mouse
Specificity
Neutralizes mouse interferon alpha; binds to mouse interferon alpha
Source
Monoclonal Rat IgG1 Clone # RMMA-1
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse Interferon alpha
Formulation
50mM Sodium Bicarbonate; 0.2M Sodium Chloride, pH 8.0
Endotoxin Level
<1.0 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
ELISA
Please refer to the PDF datasheet for specifications.
Neutralization

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Re-freezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

References
  1. Asselin-Paturel, C. et al. 2005, J. Exp. Med. 201:1157.
  2. Mellor, A.L. et al. 2005, J. Immunol. 175:5601.
Long Name
Interferon alpha
Entrez Gene IDs
3440 (Human)
Alternate Names
IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2; LeIF D

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Citations for Mouse IFN-alpha Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Neutrophils homing into the retina trigger pathology in early age-related macular degeneration
    Authors: Sayan Ghosh, Archana Padmanabhan, Tanuja Vaidya, Alan M. Watson, Imran A. Bhutto, Stacey Hose et al.
    Communications Biology
  2. Postoperative plasmacytoid dendritic cells secrete IFN-alpha to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence
    Authors: K Man, L Pang, OWH Yeung, KTP Ng, H Liu, J Zhu, J Liu, X Yang, T Ding, W Qiu, Y Wang, TLS Chiu, Z Chen, CM Lo
    Cancer Research, 2022-11-15;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  3. Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.
    Authors: Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R, Ovecka M, Prince R, Goodall L, Sepp A, Walker A
    PLoS ONE, 2015-02-17;10(2):e0117847.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development
  4. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
    Authors: von Buttlar H, Siegemund S, Buttner M, Alber G
    PLoS ONE, 2014-08-29;9(8):e106188.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  5. Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
    Authors: Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G
    J Biol Chem, 2013-11-05;288(51):36473-83.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  6. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
    Authors: Qin L, Greenland JR, Moriya C
    J. Virol., 2007-07-25;81(19):10606-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization

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